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Twelvepatients with DCI were studied by trending the daily mean alpha power against the modu-lation of treatment and clinical evolution. Other proteins impair their physical separationby imposing spatial separation (see below).
Disruptionof these complexes or inhibition of chaperone activity releases both E3 ubiquitinligases from inhibition and triggers mutant p53 degradation [ 34 , 35 ].
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